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DNA hypermethylation during tuberculosis dampens host immune responsiveness

10 Mar 2020

Abstract excerpt

Mycobacterium tuberculosis (M. tuberculosis) has coevolved with humans for millennia and developed multiple mechanisms to evade host immunity. Restoring host immunity in order to improve outcomes and potentially shorten existing therapy will require identification of the full complement by which host immunity is inhibited. Perturbation of host DNA methylation is a mechanism induced by chronic infections such as...

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PMID: 32125282
DOI: 10.1172/jci134622

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