Article

Hierarchical tissue structure creates history-dependent barriers to clonal invasion

2026-08-10

Abstract excerpt

Tissues of higher organisms are maintained by hierarchies of stem and progenitor cell compartments regulated by homeostatic feedback. Somatic mutations generate genetically distinct clones whose evolutionary success depends not only on their fitness but also on the tissue architecture in which they arise. In previous work, we showed that this hierarchical organization creates invasion barriers that prevent advanta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3cf0e040-63e7-5b0f-a0ec-7180f301b269
DOI: 10.64898/2026.08.04.742588

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hierarchical tissue structure creates history-dependent barriers to clonal invasionDOI 10.64898/2026.08.04.742588Read

A compartment size-dependent selective threshold limits mutation accumulation in hierarchical tissues.Semantic proximity Read

A compartment size dependent selective threshold limits mutation accumulation in hierarchical tissuesSemantic proximity Read

A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues.Semantic proximity Read

Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organizationSemantic proximity Read

Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization.Semantic proximity Read

A mathematical model of cancer stem cell driven tumor initiation: implications of niche size and loss of homeostatic regulatory mechanisms.Semantic proximity Read

Preventing clonal evolutionary processes in cancer: Insights from mathematical models.Semantic proximity Read

The invasion of de-differentiating cancer cells into hierarchical tissuesSemantic proximity Read

Optimizing homeostatic cell renewal in hierarchical tissues.Semantic proximity Read

Dynamically adjusted cell fate decisions and resilience to mutant invasion during steady-state hematopoiesis revealed by an experimentally parameterized mathematical model.Semantic proximity Read

Stochastic tunneling and metastable states during the somatic evolution of cancer.Semantic proximity Read

Should tissue structure suppress or amplify selection to minimize cancer risk?Semantic proximity Read