Article

Cellular Uptake and Fate of Cationic Polymer-Coated Nanodiamonds Delivering siRNA: A Mechanistic Study

2023-11-05

Abstract excerpt

<h4>ABSTRACT</h4> Gene silencing using small interfering RNAs (siRNAs) is a selective and promising approach for treatment of numerous diseases. However, broad applications of siRNAs are compromised by their low stability in a biological environment and limited ability to penetrate cells. Nanodiamonds (NDs) coated with cationic polymers can enable cellular delivery of siRNAs. Recently, we developed a new type of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1047756d-718c-5b9e-ba1e-ccff04c989d8
DOI: 10.1101/2023.11.02.564900

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cellular Uptake and Fate of Cationic Polymer-Coated Nanodiamonds Delivering siRNA: A Mechanistic StudyDOI 10.1101/2023.11.02.564900Read

A comprehensive update of siRNA delivery design strategies for targeted and effective gene silencing in gene therapy and other applicationsSemantic proximity Read

Nanoparticles co-delivering siRNA and mRNA for simultaneous restoration and silencing of gene/protein expression <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read

Non-viral nucleic acid containing nanoparticles as cancer therapeuticsSemantic proximity Read

Nano-based delivery of RNAi in cancer therapySemantic proximity Read

Nanoparticulate RNA delivery systems in cancerSemantic proximity Read

Non-cationic RGD-containing protein carrier for tumor-targeted siRNA deliverySemantic proximity Read

Multi-protein silencing using WRAP-based nanoparticles: a proof of conceptSemantic proximity Read

SCAD Delivery Platform: A Novel Approach for Efficient CNS and Extrahepatic Oligonucleotide TherapeuticsSemantic proximity Read

Nanoparticle-mediated delivery of therapeutic genes: focus on miRNA therapeuticsSemantic proximity Read

A Mechanistic Study on the Cellular Uptake, Intracellular Trafficking, and Antisense Gene Regulation of Bottlebrush Polymer-Conjugated OligonucleotidesSemantic proximity Read

Significance and applications of nanoparticles in siRNA delivery for cancer therapy.Semantic proximity Read

Nanoparticle-mediated mRNA delivery to TNBC PDX tumorsSemantic proximity Read