Nanoparticle-mediated mRNA delivery to TNBC PDX tumors

Abstract excerpt

<title>Abstract</title> <p>mRNA-based therapies can overcome several challenges faced by traditional therapies in treating a variety of diseases by selectively modulating genes/proteins without genomic integration. However, due to mRNA’s poor stability and inherent limitations, nanoparticle (NP) platforms have been developed to deliver functional mRNA into cells. In cancer treatment, mRNA technology has multiple...

Topics

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• CAR-T cell therapy research
• Immunotherapy and Immune Responses
• Monoclonal and Polyclonal Antibodies Research
• RNA Interference and Gene Delivery
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

bebcf3d1-f207-5220-927b-1e2b952b1a74

DOI

10.21203/rs.3.rs-4892937/v1