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Nanoparticle-mediated delivery of therapeutic genes: focus on miRNA therapeutics

5 Jul 2013

Abstract excerpt

INTRODUCTION: Micro RNAs (miRNA) are 21 - 23 nucleotides long and regulate the expression of coding genes by binding imperfectly with their 3' UTR region. The miRNA profile is altered in pathological processes, making miRNAs good targets for drug therapy. Restoration of down-regulated miRNA or inhibition of overexpressed miRNA to return miRNA to its normal state is the basis of miRNA-based therapy. This review...

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PMID: 23826971
DOI: 10.1517/17425247.2013.798640

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