Article

Aberrant induction of p19 <sup>Arf</sup> -mediated cellular senescence contributes to neurodevelopmental defects

2021-05-29

Abstract excerpt

Timely induction of cellular senescence is important during embryonic development and tissue repair, while aberrant activation contributes to many age-related diseases. However, whether abnormal induction of senescence in the embryo contributes to developmental defects remains unclear. To explore this, we investigated the clinically significant model of Valproic acid- (VPA) induced developmental defects. VPA is a...

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Literature Corpus work: 10358994-c2b4-563c-bd98-486ecb6ebb92
DOI: 10.1101/2021.05.28.446099

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