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All-trans Retinoic Acid regulates cellular senescence of mouse embryonic palatal mesenchyme (MEPM) cells in developing cleft palates

13 Aug 2025

Abstract excerpt

BACKGROUND: Non-syndromic cleft lip and palate is one of the most common congenital craniofacial malformations, however, its mechanism is not well understood. A number of relevant studies have confirmed that the cleft lip and palate is caused by the interaction of environmental and genetic factors. Retinoic acid is one of the metabolites of vitamin A and is involved in various physiological functions in the body,...

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PMID: 40816688
DOI: 10.1016/j.reprotox.2025.109030

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