Article
Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells.
Cell reports - 31 Aug 2021
Zhu Qian, Chen Liping, Li Ying, Huang Minghe, Shao Jingyuan, Li Shen, Cheng Juanxian, Yang Haihong, Wu Yan, Zhang Jiyan, Feng Jiannan, Fan Ming, Wu Haitao
Abstract excerpt
Normal neurodevelopment relies on intricate signaling pathways that balance neural stem cell (NSC) self-renewal, maturation, and survival. Disruptions lead to neurodevelopmental disorders, including microcephaly. Here, we implicate the inhibition of NSC senescence as a mechanism underlying neurogenesis and corticogenesis. We report that the receptor for activated C kinase (Rack1), a family member of WD40-repeat...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.