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Senescence‐Associated Molecular and Epigenetic Alterations in Mesenchymal Stem Cell Cultures from Amniotic Fluid of Normal and Fetus‐Affected Pregnancy

1 Jan 2016

Abstract excerpt

Human amniotic‐fluid‐derived mesenchymal stem cells (AF‐MSCs) are interesting for their multilineage differentiation potential and wide range of therapeutic applications due to the ease of culture expansion. However, MSCs undergo replicative senescence. So far, the molecular mechanisms that underlie fetal diseases and cell senescence are still poorly understood. Here, we analyzed senescence‐associated...

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PMID: 27803714
DOI: 10.1155/2016/2019498

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