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Emerging role of cellular senescence in normal lung development and perinatal lung injury

1 Mar 2024

Abstract excerpt

Cellular senescence is a status of irreversible growth arrest, which can be triggered by the p53/p21cip1 and p16INK4/Rb pathways via intrinsic and external factors. Senescent cells are typically enlarged and flattened, and characterized by numerous molecular features. The latter consists of increased surfaceome, increased residual lysosomal activity at pH 6.0 (manifested by increased activity of...

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PMID: 38567372
DOI: 10.1016/j.pccm.2024.01.001

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