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Article

The Anti-Amyloid-β and Neuroprotective Properties of a Novel Tricyclic Pyrone Molecule.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Maezawa Izumi, Zou Bende, Di Lucente Jacopo, Cao William S, Pascual Conrado, Weerasekara Sahani, Zhang Man, Xie Xinmin Simon, Hua Duy H, Jin Lee-Way

Abstract excerpt

There is an urgent unmet need for new therapeutics for Alzheimer's disease (AD), the most common cause of dementia in the elderly. Therapeutic approaches targeting amyloid-β (Aβ) and its downstream toxicities have become major strategies in AD drug development. We have taken a rational design approach and synthesized a class of tricyclic pyrone (TP) compounds that show anti-Aβ and other neuroprotective actions....

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Identifiers

PMID: 28482635
DOI: 10.3233/JAD-161175
PMCID: PMC5438482

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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