Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integration-free induced pluripotent stem cells model genetic and neural developmental features of down syndrome etiology.

Stem cells (Dayton, Ohio) - 1 Mar 2013

Briggs James A, Sun Jane, Shepherd Jill, Ovchinnikov Dmitry A, Chung Tung-Liang, Nayler Sam P, Kao Li-Pin, Morrow Carl A, Thakar Nilay Y, Soo Set-Yen, Peura Teija, Grimmond Sean, Wolvetang Ernst J

Abstract excerpt

Down syndrome (DS) is the most frequent cause of human congenital mental retardation. Cognitive deficits in DS result from perturbations of normal cellular processes both during development and in adult tissues, but the mechanisms underlying DS etiology remain poorly understood. To assess the ability of induced pluripotent stem cells (iPSCs) to model DS phenotypes, as a prototypical complex human disease, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down Syndrome
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Induced Pluripotent Stem Cells

Share to Neurites

Share to Neurogenesis

Share to Neurons

Share to Transcriptome

Source

Identifiers

PMID: 23225669
DOI: 10.1002/stem.1297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integration-free induced pluripotent stem cells model genetic and neural developmental features of down syndrome etiology.PMID 23225669Read ↗

Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21Semantic proximity Read ↗

Concise review: new paradigms for Down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease.Semantic proximity Read ↗

Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and NeurodegenerationSemantic proximity Read ↗

Deficits in human trisomy 21 iPSCs and neurons.Semantic proximity Read ↗

Generation of disease-specific induced pluripotent stem cells from patients with different karyotypes of Down syndromeSemantic proximity Read ↗

Induced pluripotent stem cells as a cellular model for studying Down SyndromeSemantic proximity Read ↗

Single-cell RNA sequencing of neural stem cells derived from human trisomic iPSCs reveals the abnormalities during neural differentiation of Down syndromeSemantic proximity Read ↗

A dynamic in vitro model of Down syndrome neurogenesis with trisomy 21 gene dosage correctionSemantic proximity Read ↗

Transcriptome and Proteome Profiling of Neural Induced Pluripotent Stem Cells from Individuals with Down Syndrome Disclose Dynamic Dysregulations of Key Pathways and Cellular FunctionsSemantic proximity Read ↗

Generation of Integration-Free Induced Pluripotent Stem Cells from Urine-Derived Cells Isolated from Individuals with Down SyndromeSemantic proximity Read ↗

Transcriptional consequences of trisomy 21 on neural inductionSemantic proximity Read ↗

Analysis of genotype effects and inter-individual variability in iPSC-derived trisomy 21 neural progenitor cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.