Article

Bindarit ameliorates doxorubicin-induced ovarian damage by suppressing CCL8-dependent macrophage infiltration and NF-κB-mediated inflammation

2026-03-07

Abstract excerpt

<title>Abstract</title> <p> Doxorubicin (DOX), a widely used chemotherapeutic agent, induces severe ovarian damage resulting in premature ovarian insufficiency and reduced fertility. In the present study, through transcriptome sequencing and immune cell infiltration analysis, we demonstrated that DOX significantly upregulates ovarian CCL8 expression, thereby activating the CCL8/CCR5 axis to promote the recruitme...

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Literature Corpus work: 0fde44fb-8fcb-52ec-9a98-f17e83efa6e3
DOI: 10.21203/rs.3.rs-8939659/v1

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