Article

AMH protects the ovary from doxorubicin by regulating cell fate and the response to DNA damage

2024-05-23

Abstract excerpt

<h4>Summary</h4> Anti-Müllerian hormone (AMH) protects the ovarian reserve from chemotherapy, and this effect is most pronounced with Doxorubicin (DOX). However, the mechanisms of DOX toxicity and AMH rescue in the ovary remain unclear. Herein, we characterize these mechanisms in various ovarian cell types using scRNAseq. In the mesenchyme, DOX activates the intrinsic apoptotic signaling pathway through p53 class...

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Literature Corpus work: 1677c8f5-f3eb-5ae6-8e60-efd0175616b9
DOI: 10.1101/2024.05.23.595356

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