Article

In Situ Gene Therapy Rescues Doxorubicin-induced Ovarian Damage via Adenovirus Mediated Sirt1 and Tgfbr2

2021-09-10

Abstract excerpt

<title>Abstract</title> <p>Chemotherapy-induced ovarian damage and fertility loss have negative impacts on the quality of life for female cancer patients worldwide. Thus, we aimed to explore the feasibility and safety of gene therapy for prevention of such damage. First, we validated doxorubicin-induced ovarian damage in human and mouse ovarian tissues and identified two key genes (<italic>Sirt1</italic> and <ita...

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Literature Corpus work: 5ed9e978-4094-50d7-888d-01e33e3bb217
DOI: 10.21203/rs.3.rs-843854/v1

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