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Cyclophosphamide chemotherapy induces early p53-directed cytotoxic gene expression changes in ovarian gonadotoxicity

2025-12-08

Abstract excerpt

The alkylating chemotherapeutic cyclophosphamide (CPA) is gonadotoxic, commonly resulting in depletion of ovarian primordial follicles and leading to infertility and premature menopause in female cancer patients. However, the mechanisms underlying the early stages of CPA-induced ovarian damage are unclear, limiting our ability to prevent gonadotoxicity. This study provides a comprehensive temporal exploration of t...

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Literature Corpus work
8d5e663d-9923-5a23-9b95-1ff22870902b
DOI
10.64898/2025.12.04.691500
Open publication

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Cyclophosphamide chemotherapy induces early p53-directed cytotoxic gene expression changes in ovarian gonadotoxicityDOI 10.64898/2025.12.04.691500
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