Article

BFGF Mitigates CTX-Induced Ovarian Cytotoxicity via SERPINE1/HIF-1 and Nrf-2/HO-1 Signaling Pathways

2025-05-06

Abstract excerpt

<title>Abstract</title> <p>Chemotherapy-induced ovarian damage is a significant concern for female cancer patients, often resulting in infertility, hormonal imbalance, and premature ovarian failure. Cyclophosphamide (CTX), a widely used chemotherapeutic agent, is highly effective against tumors but causes severe ovarian cytotoxicity. This study explores the protective effects of basic fibroblast growth factor (BF...

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Literature Corpus work: ace3ad47-e41b-5c8a-8199-22d4597e5b92
DOI: 10.21203/rs.3.rs-6396471/v1

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