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CCL4/CCR5 regulates chondrocyte biology and OA progression

5 Sept 2024

Abstract excerpt

BACKGROUND: Osteoarthritis (OA) is a common musculoskeletal disorder characterized by chondrocyte apoptosis and extracellular matrix degradation. This study aimed to investigate the role of CCL4/CCR5 in regulating chondrocyte apoptosis and reactive oxygen species (ROS) levels in OA progression. METHODS: Bioinformatics analysis was employed to identify CCL4 as the target gene, following which primary chondrocytes...

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PMID: 39236430
DOI: 10.1016/j.cyto.2024.156746

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