Article

CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex

2019-10-21

Abstract excerpt

The exon junction complex (EJC) is an essential constituent and regulator of spliced messenger ribonucleoprotein particles (mRNPs) in metazoans. As a core component of the EJC, CASC3 was described to be pivotal for EJC-dependent nuclear and cytoplasmic processes. However, recent evidence suggests that CASC3 functions differently from other EJC core proteins. Here, we have established human CASC3 knockout cell line...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ecf879b0-6620-50fc-a0c4-862112ccafe9
DOI: 10.1101/811018

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complexDOI 10.1101/811018Read

The exon junction complex undergoes a compositional switch that alters mRNP structure and nonsense-mediated mRNA decay activitySemantic proximity Read

Exon junction complex-associated multi-adapter RNPS1 nucleates splicing regulatory complexes to maintain transcriptome surveillanceSemantic proximity Read

Exon Junction Complexes: Supervising the Gene Expression Assembly Line.Semantic proximity Read

Stop codon-proximal 3′UTR introns in vertebrates can elicit EJC-dependent Nonsense-Mediated mRNA DecaySemantic proximity Read

Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolboxSemantic proximity Read

Function and pathological implications of exon junction complex factor Y14.Semantic proximity Read

PYM1 limits non-canonical Exon Junction Complex occupancy in a gene architecture dependent manner to tune mRNA expressionSemantic proximity Read

Nanopore sequencing reveals endogenous NMD-targeted isoforms in human cellsSemantic proximity Read

The rules and impact of nonsense-mediated mRNA decay in human cancers.Semantic proximity Read

CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes.Semantic proximity Read

Clinical significance of mRNA nonstop decay in rare disease diagnosis and recommendations for its application in variant classificationSemantic proximity Read

Regulation of nonsense-mediated mRNA decay in neural development and disease.Semantic proximity Read