Multimodality imaging and transcriptomics to phenotype mitral valve dystrophy in a unique knock-in Filamin-A rat model.

doi:10.1093/cvr/cvac136

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Article

Multimodality imaging and transcriptomics to phenotype mitral valve dystrophy in a unique knock-in Filamin-A rat model.

Cardiovascular research - 2 May 2023

Delwarde Constance, Toquet Claire, Aumond Pascal, Kayvanjoo Amir Hossein, Foucal Adrien, Le Vely Benjamin, Baudic Manon, Lauzier Benjamin, Blandin Stéphanie, Véziers Joëlle, Paul-Gilloteaux Perrine, Lecointe Simon, Baron Estelle, Massaiu Ilaria, Poggio Paolo, Rémy Séverine, Anegon Ignacio, Le Marec Hervé, Monassier Laurent, Schott Jean-Jacques, Mass Elvira, Barc Julien, Le Tourneau Thierry, Merot Jean, Capoulade Romain

Abstract excerpt

AIMS: Degenerative mitral valve dystrophy (MVD) leading to mitral valve prolapse is the most frequent form of MV disease, and there is currently no pharmacological treatment available. The limited understanding of the pathophysiological mechanisms leading to MVD limits our ability to identify therapeutic targets. This study aimed to reveal the main pathophysiological pathways involved in MVD via the multimodality...

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PMID: 36001550
DOI: 10.1093/cvr/cvac136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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