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Spatial transcriptomics reveals layered immune-metabolic architecture of giant cell myocarditis

2025-12-18

Abstract excerpt

Giant cell myocarditis (GCM) represents the most fulminant form of inflammatory cardiomyopathy, yet its spatial pathophysiology remains poorly defined. We applied full-transcriptome spatial capture in-situ RNA sequencing to a human GCM explant, generating a comprehensive high-resolution molecular atlas across twelve cardiac localizations. Spatial clustering and cell-type deconvolution delineated a complex cellular...

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Literature Corpus work
0ba23f12-71a1-51b0-9a2b-38df040b107b
DOI
10.64898/2025.12.15.25342188
Open publication

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Spatial transcriptomics reveals layered immune-metabolic architecture of giant cell myocarditisDOI 10.64898/2025.12.15.25342188
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