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Article

Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer

5 Jul 2018

Abstract excerpt

The expression of fucosyltransferase 8, an enzyme responsible for core fucosylation encoded by FUT8, influences tumor biology and correlates with patient prognosis in several solid cancers. We hypothesized that p53 alteration modifies prognostic associations of FUT8 expression in colorectal cancer (CRC), since FUT8 has recently been identified as a direct transcriptional target of wild-type p53. Utilizing...

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PMID: 29975776
DOI: 10.1371/journal.pone.0200315

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