Article

EGFR core fucosylation, induced by enveloped viruses, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses

2023-06-21

Abstract excerpt

<title>Abstract</title> <p>Aberrant N-glycosylation has been implicated in viral diseases. Alpha-(1,6)-fucosyltransferase (FUT8) is the sole enzyme responsible for core fucosylation of N-glycans during glycoprotein biosynthesis. Here we found that multiple viral envelope proteins (including HCV-E2, VSV-G, SARS-COV-2-Spike and HIV-gp120) enhanced FUT8 expression and core fucosylation. HCV-E2 manipulates host trans...

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Literature Corpus work: 50a7fbb7-daf7-50f6-b3d2-d1cf6c4a0320
DOI: 10.21203/rs.3.rs-3062366/v1

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EGFR core fucosylation, induced by enveloped viruses, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defensesDOI 10.21203/rs.3.rs-3062366/v1Read

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