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Article

Loss of α1,6-fucosyltransferase suppressed liver regeneration: implication of core fucose in the regulation of growth factor receptor-mediated cellular signaling.

Scientific reports - 5 Feb 2015

Wang Yuqin, Fukuda Tomohiko, Isaji Tomoya, Lu Jishun, Gu Wei, Lee Ho-Hsun, Ohkubo Yasuhito, Kamada Yoshihiro, Taniguchi Naoyuki, Miyoshi Eiji, Gu Jianguo

Abstract excerpt

Core fucosylation is an important post-translational modification, which is catalyzed by α1,6-fucosyltransferase (Fut8). Increased expression of Fut8 has been shown in diverse carcinomas including hepatocarcinoma. In this study, we investigated the role of Fut8 expression in liver regeneration by using the 70% partial hepatectomy (PH) model, and found that Fut8 is also critical for the regeneration of liver....

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Identifiers

PMID: 25652335
DOI: 10.1038/srep08264
PMCID: PMC4317695

Genes

EGF
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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