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Immunogenicity of Monoclonal Antibodies and the Potential Use of HLA Haplotypes to Predict Vulnerable Patients

17 Jun 2022

Abstract excerpt

The use of monoclonal antibodies (mAbs) in the clinic has successfully expanded to treatment of cancer, viral infections, inflammations, and other indications. However, some of the classes of mAbs that are used in the clinic show the formation of anti-drug antibodies (ADAs) leading to loss of efficacy. This review describes ADA formation for the various mAbs, and its clinical effect. Lastly, this review considers...

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Chronic Lymphocytic Leukemia Research
Immunodeficiency and Autoimmune Disorders
Monoclonal and Polyclonal Antibodies Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35784343
DOI: 10.3389/fimmu.2022.885672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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