Article
A genome-wide miRNA screen identifies regulators of tetraploid cell proliferation
2018-02-19
Abstract excerpt
Tetraploid cells, which are most commonly generated by errors in cell division, are genomically unstable and have been shown to promote tumorigenesis. Recent genomic studies have estimated that ∼40% of all solid tumors have undergone a genome-doubling event during their evolution, suggesting a significant role for tetraploidy in driving the development of human cancers. To safeguard against the deleterious effects...
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Identifiers and source
- Literature Corpus work
- 0f468f08-2790-569d-ada4-e5488bc95989
- DOI
- 10.1101/266395