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Article

The roles of telomerase in the generation of polyploidy during neoplastic cell growth.

Neoplasia (New York, N.Y.) - 1 Feb 2013

Christodoulidou Agni, Raftopoulou Christina, Chiourea Maria, Papaioannou George K, Hoshiyama Hirotoshi, Wright Woodring E, Shay Jerry W, Gagos Sarantis

Abstract excerpt

Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies. It has been shown that telomere deprotection in p53-deficient mouse embryonic fibroblasts leads to high rates of polyploidization. We now show that tumor genome evolution through whole-genome duplication occurs in ∼15% of the karyotyped...

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Identifiers

PMID: 23441130
DOI: 10.1593/neo.121398
PMCID: PMC3579318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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