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Tetraploidization Increases the Motility and Invasiveness of Cancer Cells

10 Sept 2023

Abstract excerpt

Polyploidy and metastasis are associated with a low probability of disease-free survival in cancer patients. Polyploid cells are known to facilitate tumorigenesis. However, few data associate polyploidization with metastasis. Here, by generating and using diploid (2n) and tetraploid (4n) clones from malignant fibrous histiocytoma (MFH) and colon carcinoma (RKO), we demonstrate the migration and invasion advantage...

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PMID: 37762227
DOI: 10.3390/ijms241813926

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