Article

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

2019-07-22

Abstract excerpt

Mutations that activate LRRK2 protein kinase cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction with effectors. An siRNA screen of all protein phosphatases revealed that a poorly studied protein phosphatase, PPM1H, counteracts LRRK2 signaling by specifically dephosphorylating Rab proteins. PPM1H knock out increased endogenous Rab phosphoryla...

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Literature Corpus work: 0ef43293-bc14-54aa-8b7a-0ba506e92a16
DOI: 10.1101/711176

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