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EBI2 in splenic and local immune responses and in autoimmunity

9 May 2018

Abstract excerpt

The seven transmembrane G protein-coupled receptor EBV-induced gene 2 (EBI2), also known as GPR183, is expressed in particular in immune cells. Activated by its endogenous ligands, which are a group of oxysterols, it functions as a chemo-attractant receptor, mediating cell migration. In coordination with other receptors, EBI2 plays important roles in controlling the migration of immune cells during the course of...

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PMID: 29741800
DOI: 10.1002/jlb.2vmr1217-510r

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