Article

Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming

2023-03-15

Abstract excerpt

Vaccine priming immunogens that activate germline precursors for broadly neutralizing antibodies (bnAbs) have promise for development of precision vaccines against major human pathogens. In a clinical trial of the eOD-GT8 60mer germline-targeting immunogen, higher frequencies of vaccine-induced VRC01-class bnAb-precursor B cells were observed in the high dose compared to the low dose group. Through immunoglobulin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0edf0821-4b0f-594f-ad2d-b7136da305cb
DOI: 10.1101/2023.03.10.23287126

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human immunoglobulin gene allelic variation impacts germline-targeting vaccine primingDOI 10.1101/2023.03.10.23287126Read

Human immunoglobulin gene allelic variation impacts germline-targeting vaccine primingSemantic proximity Read

Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cellsSemantic proximity Read

Vrc01-class Precursor Frequency in an African Population is Influenced by Ighv1-2 Allelic Composition and Not Malaria ExposureSemantic proximity Read

Vaccination induces HIV broadly neutralizing antibody precursors in humans.Semantic proximity Read

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.Semantic proximity Read

Binding dynamics shape germinal center broadly neutralizing responses to HIV primingSemantic proximity Read

Binding dynamics shape germinal center broadly neutralizing responses to HIV primingSemantic proximity Read

Adjuvants influence the maturation of VRC01-like antibodies during immunizationSemantic proximity Read

Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursorsSemantic proximity Read

Genetic variation in HLA, IGKV and HHEX loci influence mRNA vaccine-induced long-lasting humoral protection against COVID-19Semantic proximity Read

Universal vaccines? Only if your antibody genes agree.Semantic proximity Read

Structural insights into VRC01-class bnAb precursors with diverse light chains elicited in the IAVI G001 human vaccine trialSemantic proximity Read