Article

Adjuvants influence the maturation of VRC01-like antibodies during immunization

2022-06-13

Abstract excerpt

<h4>ABSTRACT</h4> Once naïve B cells expressing germline VRC01-class B cell receptors become activated by germline-targeting immunogens, they enter germinal centers and undergo affinity maturation. Booster immunizations with heterologous Envs are required for the full maturation of VRC01-class antibodies. Here, we examined whether and how three adjuvants, Poly(I:C), GLA-LSQ, or Rehydragel, that activate different...

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Literature Corpus work: be3c7f19-1a79-5723-bc12-1a50c7c26720
DOI: 10.1101/2022.06.10.495681

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