Article

Differential effects of Wnt-β-catenin signaling in Purkinje cells and Bergmann glia in SCA1

2021-10-21

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disease characterized by progressive ataxia and degeneration of specific neuronal populations, including Purkinje cells (PCs) in the cerebellum. Previous studies have demonstrated a critical role for various evolutionarily conserved signaling pathways in cerebellar patterning, such as the Wnt-β-catenin pathway; however, the roles of t...

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Literature Corpus work: 0ed69cd5-d497-522f-86a7-16c6a9e368cf
DOI: 10.1101/2021.10.21.465333

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