Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons.

Neuron - 1 Dec 1999

Tomoda T, Bhatt R S, Kuroyanagi H, Shirasawa T, Hatten M E

Abstract excerpt

The formation of the cerebellar circuitry depends on the outgrowth of connections between the two principal classes of neurons, granule neurons and Purkinje neurons. To identify genes that function in axon outgrowth, we have isolated a mouse homolog of C. elegans UNC51, which is required for axon formation, and tested its function in cerebellar granule neurons. Murine Unc51.1 encodes a novel serine/threonine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Cerebellum

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoplasmic Granules

Share to In Situ Hybridization

Share to Nerve Fibers

Share to Neural Pathways

Share to Neurites

Share to Retroviridae

Source

Identifiers

PMID: 10624947
DOI: 10.1016/s0896-6273(00)81031-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons.PMID 10624947Read ↗

Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase.Semantic proximity Read ↗

The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans.Semantic proximity Read ↗

Unc-51/ATG1 controls axonal and dendritic development via kinesin-mediated vesicle transport in the Drosophila brain.Semantic proximity Read ↗

Loss of the neuron-specific F-box protein FBXO41 models an ataxia-like phenotype in mice with neuronal migration defects and degeneration in the cerebellum.Semantic proximity Read ↗

The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathwaySemantic proximity Read ↗

Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans.Semantic proximity Read ↗

Loss of the Familial Dysautonomia gene <i>Elp1</i> in cerebellar granule cell progenitors leads to ataxia in miceSemantic proximity Read ↗

Loss of Elp1 in cerebellar granule cell progenitors models ataxia phenotype of Familial Dysautonomia.Semantic proximity Read ↗

The <i>Caenorhabditis elegans</i> gene <i>unc-76</i> and its human homologs define a new gene family involved in axonal outgrowth and fasciculationSemantic proximity Read ↗

Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1.Semantic proximity Read ↗

Differential effects of Wnt-β-catenin signaling in Purkinje cells and Bergmann glia in SCA1Semantic proximity Read ↗

PLR-1, a putative E3 ubiquitin ligase, controls cell polarity and axonal extensions in C. elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.