Article
Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1.
eLife - 23 Dec 2014
Kim Edward, Wang Yuan, Kim Sun-Jung, Bornhorst Miriam, Jecrois Emmanuelle S, Anthony Todd E, Wang Chenran, Li Yi E, Guan Jun-Lin, Murphy Geoffrey G, Zhu Yuan
Abstract excerpt
Individuals with neurofibromatosis type 1 (NF1) frequently exhibit cognitive and motor impairments and characteristics of autism. The cerebellum plays a critical role in motor control, cognition, and social interaction, suggesting that cerebellar defects likely contribute to NF1-associated neurodevelopmental disorders. Here we show that Nf1 inactivation during early, but not late stages of cerebellar development,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.