Article

Increased alpha-helicity of a supercharged coiled-coil protein increases siRNA delivery efficiency of protein-lipid hybrid vehicle

2021-05-04

Abstract excerpt

Gene therapy has the potential to treat various diseases and has recently gained new interest due to the deployment nucleic acid based vaccines for COVID-19. Despite these developments, there still remains a need for further development of gene delivery vehicles to increase their safety and efficacy.. We have recently developed a lipoproteoplex (LPP) consisting of a super-charged coiled-coil protein (CSP) and a ca...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0eba6bb7-743b-5348-8b94-27d2ada21566
DOI: 10.1101/2021.05.03.442303

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Increased alpha-helicity of a supercharged coiled-coil protein increases siRNA delivery efficiency of protein-lipid hybrid vehicleDOI 10.1101/2021.05.03.442303Read

Rational Design of Unsaturated, Thioether Ionizable Lipids for Enhanced <i>In vivo</i> mRNA DeliverySemantic proximity Read

Modular Protein Engineering in Emerging Cancer TherapiesSemantic proximity Read

Lipid Nanoparticle Delivery of Small Proteins for Potent In Vivo RAS InhibitionSemantic proximity Read

Multi-protein silencing using WRAP-based nanoparticles: a proof of conceptSemantic proximity Read

Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing <i>in vivo</i>Semantic proximity Read

A Rapidly Excretable, ROS-Scavenging Ionizable Lipid Decouples mRNA Delivery Potency from ToxicitySemantic proximity Read

Delineating effect of cationic head group and preparation method on transfection versus toxicity of lipid-based nanoparticles for gene deliverySemantic proximity Read

Solid lipid nanoparticles for applications in gene therapy: a review of the state of the artSemantic proximity Read

Modular supramolecular polycations enable efficient delivery of RNA therapeutics and vaccinesSemantic proximity Read

Isoprenoid CARTs: In Vitro and In Vivo mRNA Delivery by Charge-Altering Releasable Transporters Functionalized with Archaea-inspired Branched LipidsSemantic proximity Read

Optimization of human papillomavirus-based pseudovirus techniques for efficient gene transferSemantic proximity Read

γ-Amino acid mutated α-coiled coils as mild thermal triggers for liposome delivery.Semantic proximity Read