Modular supramolecular polycations enable efficient delivery of RNA therapeutics and vaccines

Abstract excerpt

<title>Abstract</title> <p>We describe a modular, diverse and customisable supramolecular-materials platform which can deliver nucleic acids<italic> in vitro</italic> and <italic>in vivo </italic>with reduced immunogenicity and enhanced stability compared to lipid analogues. The chemistries deployed enable the generation of multiple host-guest polycationic structures which can associate with RNA to form polyelect...

Topics

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• Advanced biosensing and bioanalysis techniques
• Animal Virus Infections Studies
• Cancer Research and Treatment
• Monoclonal and Polyclonal Antibodies Research
• RNA Interference and Gene Delivery
• Viral gastroenteritis research and epidemiology
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

9eeb11a0-5ed3-59b2-8995-f4399efbd795

DOI

10.21203/rs.3.rs-6849219/v1