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Lipid Nanoparticle Delivery of Small Proteins for Potent In Vivo RAS Inhibition

28 Apr 2023

Abstract excerpt

Mutated RAS proteins are potent oncogenic drivers and have long been considered “undruggable”. While RAS-targeting therapies have recently shown promise, there remains a clinical need for RAS inhibitors with more diverse targets. Small proteins represent a potential new therapeutic option, including K27, a designed ankyrin repeat protein (DARPin) engineered to inhibit RAS. However, K27 functions intracellularly...

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PMID: 37115558
DOI: 10.1021/acsami.3c01501

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