Article

IKAROS Gene Regulatory Network Reveal ERG as a Vulnerability in B-cell Acute Lymphoblastic Leukemia

2025-12-29

Abstract excerpt

B-cell acute lymphoblastic leukemia (B-ALL) is driven by transcriptional dysregulation that impairs B-cell differentiation and sustains leukemic growth. A defining feature of high-risk B-ALL is mutations in IKZF1 , which encodes the tumor suppressor IKAROS. Here, we map IKAROS gene regulatory networks in IKZF1 -mutated Ph B-ALL using an inducible IKAROS system and multi-omic profiling. IKAROS restoration reprogr...

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Literature Corpus work: 283e5660-01c8-5b3e-98df-011025a7faa0
DOI: 10.64898/2025.12.29.696402

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