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Article

Conserved helical motifs in the IKZF1 disordered region mediate NuRD interaction and transcriptional repression

22 Oct 2024

Abstract excerpt

ABSTRACT: The transcription factor (TF) Ikaros zinc finger 1 (IKZF1) is essential for B-cell development, and recurrently mutated in human B-cell acute lymphoblastic leukemia (B-ALL). IKZF1 has been ascribed both activating and repressive functions via interactions with coactivator and corepressor complexes, but the relative abundance of IKZF1-associated coregulators and their contribution to IKZF1-mediated gene...

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PMID: 39437550
DOI: 10.1182/blood.2024024787

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