Article

Decoding Amyloid Plaque Penetrability: Exploring Extracellular Space and Rheology in Plaque-rich Cortex

2025-08-27

Abstract excerpt

A hallmark of Alzheimer’s disease (AD) is the accumulation of amyloid plaques, primarily composed of misfolded amyloid β (Aβ) peptides. We employed complementary high-resolution imaging techniques to investigate the plaque penetrability and the extracellular space (ECS) rheology in a mouse model of AD. Two-photon shadow imaging in vivo confirmed that a dense ring of cells surrounds cortical amyloid plaques but hi...

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Literature Corpus work: 0eb183ee-9196-548a-a79c-9cca117cf62a
DOI: 10.1101/2025.08.24.671960

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