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A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF

12 Jun 2024

Abstract excerpt

To date, earlier diagnosis of Alzheimer's disease (AD) is still challenging. Recent studies revealed the elevated expression of connective tissue growth factor (CTGF) in AD brain is an upstream regulator of amyloid-beta (Aβ) plaque, thus CTGF could be an earlier diagnostic biomarker of AD than Aβ plaque. Herein, we develop a peptide-coated gold nanocluster that specifically targets CTGF with high affinity (KD ~...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38866763
DOI: 10.1038/s41467-024-49409-4

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