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Modeling gastric intestinal metaplasia in 3D organoids using nitrosoguanidine

1 Jul 2024

Abstract excerpt

Gastric intestinal metaplasia (GIM) represents a precancerous stage characterized by morphological and pathophysiological changes in the gastric mucosa, where gastric epithelial cells transform into a phenotype resembling that of intestinal cells. Previous studies have demonstrated that the intragastric administration of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) induces both gastric carcinoma and intestinal...

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PMID: 39153963
DOI: 10.1093/jmcb/mjae030

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