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Article

Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo

20 Nov 2017

Abstract excerpt

Retinoic acid receptor-related-orphan-receptor-C (RORγt) is the key transcription factor that is driving the differentiation of IL-17 producing T-helper 17 (Th17) cells that are implicated in the pathology of various autoimmune and inflammatory diseases. Based on the importance of RORγt in promoting Th17-driven pathology, there is considerable interest to develop low-molecular-weight compounds with the aim of...

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PMID: 29155882
DOI: 10.1371/journal.pone.0188391

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