Mouse T helper 17 phenotype: not so different than in man after all.

Abstract excerpt

CD4+ T-helper (TH) cells that selectively produce interleukin (IL)-17 (TH17) are thought to be critical for host defense and autoimmunity. Three major dogmas were established, based on initial studies performed in murine models, and initially extrapolated by many researchers to human pathophysiology. First, TH17 cells represent a fixed CD4+ T-cell effector phenotype without any developmental relationship with TH1...

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