Article

Sustained Humoral Activation through self-amplifying mRNA Vaccination Enhances Longitudinal Antibody Function in a Phase III Trial

2025-11-26

Abstract excerpt

<h4>Summary</h4> Sustained and functional antibody responses to respiratory pathogens through vaccination is critical for global public health. The development and deployment of mRNA vaccines during the coronavirus disease 2019 (COVID19) pandemic was a landmark achievement in modern medicine and ushered in a new age of vaccine innovation. The mRNA-based vaccines elicited strong antibody responses, both neutralizi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e70a2d0-0851-594b-b743-6ec83b38ffbe
DOI: 10.1101/2025.11.25.690547

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sustained Humoral Activation through self-amplifying mRNA Vaccination Enhances Longitudinal Antibody Function in a Phase III TrialDOI 10.1101/2025.11.25.690547Read

Humoral waning kinetics against SARS-CoV-2 is dictated by disease severity and vaccine platformSemantic proximity Read

Profiling antibody epitopes induced by mRNA-1273 vaccination and boostersSemantic proximity Read

Differential antibody dynamics to SARS-CoV-2 infection and vaccinationSemantic proximity Read

Waning and boosting of functional humoral immunity to SARS-CoV-2Semantic proximity Read

Cellular immune breadth of an Omicron-specific, self-amplifying monovalent mRNA vaccine booster for COVID-19Semantic proximity Read

Broad anti–SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccinationSemantic proximity Read

Prototype mRNA vaccines imprint broadly neutralizing human serum antibodies after Omicron variant-matched boostingSemantic proximity Read

Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccineSemantic proximity Read

Low dose mRNA-1273 COVID-19 vaccine generates durable T cell memory and antibodies enhanced by pre-existing crossreactive T cell memorySemantic proximity Read

Ad26.COV2.S priming provides a solid immunological base for mRNA-based COVID-19 booster vaccinationSemantic proximity Read

Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variantsSemantic proximity Read

mRNA Vaccine-Induced SARS-CoV-2 Spike-Specific IFN-γ and IL-2 T-cell Responses are Predictive of Serological Neutralization and are Transiently Enhanced by Pre-Existing Cross-Reactive ImmunitySemantic proximity Read