Article

<i>In vitro</i> validation of neoantigen prediction algorithm for developing personalized cancer vaccine therapy

2021-12-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The development of personalized neoantigen-based therapeutic cancer vaccines relies on computational algorithm-based pipelines. One of the critical issues in the pipeline is obtaining higher positive predictive value (PPV) performance, i.e., how many are immunogenic when selecting the top 5 to 20 candidate neoepitopes for the vaccination. We attempted to test the PPV of a ne...

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Literature Corpus work: 48304986-8903-5b58-b01d-585be001e848
DOI: 10.1101/2021.12.12.472304

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