Article

Unlocking the full potential of Oxford Nanopore reads with NOVOLoci

2025-08-12

Abstract excerpt

Long-read sequencing technologies and accompanying algorithms have substantially advanced genome assembly. However, there are ongoing challenges in assembling complex genomic regions, particularly those associated with genetic disorders. Moreover, assemblies of non-model organisms are often limited by the amount of DNA that can be extracted, so reducing the data modalities that can be obtained. Here, we introduce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0e67544d-6660-5632-a239-497645511ec3
DOI: 10.1101/2025.08.08.669243

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unlocking the full potential of Oxford Nanopore reads with NOVOLociDOI 10.1101/2025.08.08.669243Read

Extended haplotype-phasing of long-read de novo genome assemblies using Hi-C.Semantic proximity Read

De novo diploid genome assembly using long noisy reads.Semantic proximity Read

Haplotype-Resolved Assembly for Synthetic Long Reads Using a Trio-Binning StrategySemantic proximity Read

Chromosome-scale, haplotype-resolved assembly of human genomes.Semantic proximity Read

Extended haplotype phasing of <i>de novo</i> genome assemblies with FALCON-PhaseSemantic proximity Read

Telomere-to-Telomere Phased Genome Assembly Using HERRO-Corrected Simplex Nanopore ReadsSemantic proximity Read

Verkko: telomere-to-telomere assembly of diploid chromosomesSemantic proximity Read

Gapless assembly of complete human and plant chromosomes using only nanopore sequencingSemantic proximity Read

Constellation illuminates rare disease geneticsSemantic proximity Read

Haplotype-aware variant calling with PEPPER-Margin-DeepVariant enables high accuracy in nanopore long-reads.Semantic proximity Read

PhaseME: Automatic rapid assessment of phasing quality and phasing improvement.Semantic proximity Read

Complete assembly of parental haplotypes with trio binningSemantic proximity Read