Article

Exposure to nitric oxide drives transition to differential culturability in <i>Mycobacterium tuberculosis</i>

2021-09-28

Abstract excerpt

<h4>ABSTRACT</h4> During infection Mycobacterium tuberculosis (Mtb) forms differentially culturable (DC) subpopulations that are recalcitrant to treatment and undetectable using standard diagnostic tools. DC Mtb are revealed in liquid media, their revival is often stimulated by resuscitation-promoting factors (Rpfs), secreted peptidoglycan-remodelling enzymes, and prevented by Rpf inhibitors. Here we investigate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0e4c7270-e335-5da0-ae82-fc2b44bf31d6
DOI: 10.1101/2021.09.28.462152

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exposure to nitric oxide drives transition to differential culturability in <i>Mycobacterium tuberculosis</i>DOI 10.1101/2021.09.28.462152Read

Nitric oxide induces the distinct invisibility phenotype of Mycobacterium tuberculosis.Semantic proximity Read

<i>Mycobacterium tuberculosis</i> diversity and macrophage heterogeneity dictate phagosomal acidificationSemantic proximity Read

<i>Mycobacterium tuberculosis</i> evades host immunity by recruiting mesenchymal stem cellsSemantic proximity Read

Stress-responsive <i>Mycobacterium tuberculosis</i> subpopulations manipulate macrophage polarization and can be targeted to limit inflammationSemantic proximity Read

Nitrite produced by <i>Mycobacterium tuberculosis</i> in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expressionSemantic proximity Read

Species-specific iNOS expression distinguishes epithelial and myeloid IFNγ responses in tuberculosisSemantic proximity Read

Cytokine Dynamics and Oxidative Stress in Host Cells Stimulated with Drug-Resistant and Sensitive <i>Mycobacterium tuberculosis</i> IsolatesSemantic proximity Read

Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophagesSemantic proximity Read

Rv1985c-Driven Transcriptional Network Rewiring Underlies Lineage-Specific Phenotypes in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Langhans giant cells from <i>M. tuberculosis</i>‐induced human granulomas cannot mediate mycobacterial uptakeSemantic proximity Read

Detection and Quantification of Differentially Culturable Tubercle Bacteria in Sputum from Patients with TuberculosisSemantic proximity Read

Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in <i>M. tuberculosis</i> host defenseSemantic proximity Read