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Article

Nitric oxide induces the distinct invisibility phenotype of Mycobacterium tuberculosis.

Communications biology - 28 Sept 2024

Gap-Gaupool Brindha, Glenn Sarah M, Milburn Emily, Turapov Obolbek, Crosatti Marialuisa, Hincks Jennifer, Stewart Bradley, Bacon Joanna, Kendall Sharon L, Voskuil Martin I, Riabova Olga, Monakhova Natalia, Green Jeffrey, Waddell Simon J, Makarov Vadim A, Mukamolova Galina V

Abstract excerpt

During infection Mycobacterium tuberculosis (Mtb) forms physiologically distinct subpopulations that are recalcitrant to treatment and undetectable using standard diagnostics. These difficult to culture or differentially culturable (DC) Mtb are revealed in liquid media, their revival is often stimulated by resuscitation-promoting factors (Rpf) and prevented by Rpf inhibitors. Here, we investigated the role of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39342050
DOI: 10.1038/s42003-024-06912-0
PMCID: PMC11439070

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